Barelavvats alfa-ketoamidnere karox en SARS-CoV-2-i dem patvastanyuti himq darnal
Gitnakannern organizmum pahman aravel erkaratsvats zhamanak unetsox ketoamidner en statsel: Ayd nyute karox e hakavirusayin dexamijotsneri stextsman hamar himq handisanal:
Germaniayi ev Chinastani hetazotoxneri xumbe karoxatsel e barelavel mardu organizmi alfa-ketoamidneri molekulneri aktivutyune: Da pandemia arajatsrats koronavirusi dem ashxatanqayin dexamijotsi statsman huys e nershnchum:
Alfa-ketoamidnere SARS-CoV-2 harutschi glxavor proteazi (proteolitik ferment) inhibitornern en (zspich): Glxavor proteaze xist karevor e virusi krknapatkman hamar: Ayn tshexqum e varakvats bjji koxmits sintezavorvox aminattvayin shxtanere minchev hajordakanutyunnere, orontsits heto dzevavorvum en virusayin spitakutsnere:
Koronavirusi glxavor proteaze lav usumnasirvats e ev vaxuts ditarkvel e gitnakanneri koxmits, orpes patvastanyuti stextsman herankarayin tirax: Petrvar amsin arajin angam statsvel en ketoamidneri hamaxmbere, oronq unak en tshnshelu koronavirusneri tarber shtammeri proteazneri aktivutyune: End orum nyutere och mi kerp chen xaxtel mardu sepakan fermentneri ashxatanqe:
Nor hetazotutyunum gitnakannere pordzarkel en modifikatsvats alfa-ketoamidnern enddem virusayin fermentneri: Hetazotoxnere popoxel en molekuli karutsvatsqe՝ bardzratsnelov lutseliutyune ev poxelov qimiakan karevor radikalneri dirqe՝ drants dardznelov bjjayin spitakutsneri hamar aveli xotseli: Statsvats dexanyute pordzarkel en SARS-CoV-2-i maqur glxavor proteazi, krknorinakman-poxakerpman virusayin hamaliri, inchpes naev koronavirusov varakvats mardu bjijneri vra: Gitnakannere naev hstaketsrel en alfa-ketoamidneri farmakokinetayin hatkutyunnere՝ 1 kg-i hamar 3 miligram haraberaktsutyamb nerarkelov mknerin:
Teev nor molekuli inhibatsiayi ardyunavetutyune tsatsr e exel, qan naxord pordzarkumnerum, aynuamenayniv՝ gitnakannerin hajoxvel e hasnel molekuli karevor hatkutyan bardzratsmane. nranq grete eraki metsatsrel en organizmits alfa-ketoamidneri kisadursberman (kochvum e naev kisakyanq) zhamanakashrjane: Mkneri organizmum dexamijotsi pahman zhamanake kazmel e 2,7 zham, isk plazmayits kisadursberman zhamanakahatvatse՝ 1,8 zham:
Nman ardyunqnere tsuyts en talis, or patvastanyuti mek chapaqanake karox e aveli erkar tsutsaberel hakavirusayin efekt՝ varakvats organizmum: Mkneri vra arvats pordzere, erb inhalatorneri ognutyamb nerarkel en modifikatsvats molekulner, tsuyts en tvel, or alfa-ketoamidnern enknum en anmijapes toqere (oronq Covid-19-i depqum aravel xotseli en) ev chen arajatsnum koxmnaki toqsik efektner: Gitnakanneri kartsiqov՝ modifikatsvats ketoamidnere karox en darnal SARS-CoV-2-i dem ardyunavet patvastanyuti himqe:
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