Virusi arhestakan tsagman masin xosele «patologiakan tsndabanutyun e». virusolog

Ashxarhum amenashat mejbervox virusolog ev genomneri evolyutsiayi masnaget evgeni Kunine verjers ir gortsenkerneri het ashxatutyun e hraparakel, ortex gitnakannere nkaragrum en koronavirusneri (naev SARS-CoV-2-i) aravel vtangavor ev patogen taratesaknerin bnorosh genomayin aguytsnere:

Incho՞v e nor viruse hetaqrqir kensabanneri hamar

Nerkayums entertsvats en nor koronavirusi aveli qan 4 hazar genomner, isk endhanur armamb taratesak koronavirusnerits havaqvel en aveli qan 5 hazare, aynpes or՝ virusayin evolyutsiayi hetazotoxneri hamar aystex och miayn martahraver ka, aylev՝ hetazotutyan eakan hnaravorutyunner:

Minch hetazotutyune, haytni er pangolinayin virusneri het endhanrutyan masin, arka er S spitakutsi masin texekutyune:

Pordzel enq parzel, te ardyo՞q ays koronavirusi genomum arka e ayn, inche miavorum e miayn bardzrpatogenayin virusnere ev inchn e tarberum myusnerits: Haytni bardzrpatogennern en՝ 2002t. SARS-CoV-1-e, ays SARS-CoV-2-e ev merdzavorarevelyan MERS-e: Verjins mi poqr tarbervum e myusnerits:

Oroshvel e hetazotel endhanur kape bardzrpatogenneri u tsatsr patogenneri mijev: Havasaretsvel e ayd bolor virusneri aminottvayin hajordakanutyune, arandznatsvel en ayd havasarumneri husali hatvatsnere ev dimel en meqenayatsvats usutsman metodin՝ gtnelu genomneri ayn arandznahatkutyunnere, oronq aravel hstak taranjatum en bardzrpatogenayin shtammere tsatsrpatogenayinnerits:

Incho՞v en tarbervum bardzrpatogenayin koronavirusneri genomnere

Haytnabervats aguytsnern arka en zuyg SARS, MERS ev nrants harazat virusneri genomnerum: Minchder tuylpatogenayinneri ev nrants harazatneri mot chkan: Sakayn MERS-n u 2 SARS-ere tarber uxxutyunnerum en gtnvum u ayd aguytsnern i hayt en ekel irarits ankax: Da tsuyts e talis, or dranq azdum en patogenutyan vra ev, hnaravor e, npastum en kendanuts mardun antsnelu vra:

Xosqe ereq kartsh aguytsneri masin e, oronq gtnvum en S spitakutsi erku karevor hatvatsnerum: Meke gtnvum e ayn ketin mot, ore patasxanum e tiroj ev virusi membrani miadzulman hamar: Aydtex ka naev tshkun peptid, ore dzevavorum e sharzhakan «kamurjik» depi spitakutsi myus hatvatse: Ayd kamurjike erkarum e haytnabervats aguytsov, inche metsatsnum e miavorman tshkunutyune:

Myus aguytsnere gtnvum en S spitakutsi mievnuyn texum: Erku SARS-ere mardun mianalu hamar ogtagortsum en mievnuyn membranayin spitakutse (ACE2), isk MERS-e՝ ayl: Xosqn aguytsi ayn texi masin e, orn anmijakanoren poxazdvum e retseptor-tiraxi het, ev nra karutsvatsqum erevum e, or ayd aguytsnern uzhgnatsnum en poxazdetsutyune:

Mutatsvo՞ւm e viruse ev i՞nch aragutyamb

Mutatsiayi ditarkvox aragutyunum artahaytich ochinch chka, ayn hamadreli e ayl RNT virusneri het: Patogenutyan nvazume hnaravor e: Bayts da miak uxxutyune che, orov entanum e evolyutsian:

Aystex mi sharq nrbutyunner kan, oronq petq e manramasn usumnasirven: Kan arandznahatkutyunner, oronq kaxvats en viruse kroxits:

Ortexi՞ts e haytnvel virusn u hnaravo՞r e՝ arhestakan tsagum unena

Inch-or pahi chxjikneri u pangolinneri virusneri mijev texi e unetsel verakazmavorum: Batsi ayd, i hayt en ekel nor aminattuner, oronq tuyl en talis lav amranal mardkants retseptor-tiraxnerin: Aydpes arajatsel e patogenutyan tarber hangamanqneri miavorume, ev ardyunqum viruse karox er kendanuts antsnel mardun: Sakayn ayd amene derevs manramasn hetazotutyan ararka en, qani or kendanineri mot drants dzevavorman, miavorman ev aylni masin texekutyunnere qich en:

Genomi hajordakanutyan hetazotutyune tsuyts e talis, or virusn arhestakanoren chi stextsvel: Hakarak pndume patologiakan tsnorq e:

Qnnarkvum e naev ayn tarberake, or inch-or meke laboratoriayum usumnasirvel e chxjikneri viruse, ev hetazotoxe varakvel e, apa՝ poxantsel urishneri: Ays hartsin patasxanelu hamar lrjaguyn hetazotutyun e anhrazhesht:

Aguytsneri hetazotutyune tsuyts e tvel, or och oq mitumnavor och mi shtamm chi stextsel: Gitnakanneri koxmits nor virusneri stextsman veraberyal՝ da aynqan el dyurin gorts che: Hnaravor e kanxatesel, te stextsvatsn inch ardyunq kunena, sakayn mianshanak hamozvats linel chi lini: