Kanadatsi gitnakannere haxordel en, or remdesivirn ardyunavet kerpov kasetsnum e SARS-CoV-2 virusi bazmatsume

Albertayi hamalsarani hetazotoxnern ashxatutyun en hraparakel` hastatelov, or hakavirusayin remdesivir dexamijotsn ardyunavet kerpov kasetsnum e koronavirusi krknorinakume (replikatsia): Nuyn gitnakannern aveli vax haytnel ein, or dexamijotse lav e gortsum MERS-CoV-i` merdzavorarevelyan shncharakan hamaxtanishi dem:

Remdesivire zspox RNT-kaxyal RNT-polimerazner dasi hakavirusayin dexamijots e (aydtesak polimeraznerits e ogtvum SARS-CoV-2 viruse): Ayn mshakvel e 2015t. AMN-i banaki varakayin hivandutyunneri hetazotakan instituti masnagetneri koxmits: Remdisivire laynoren kirarvel e Ebolayi tendi hamatsharaki zhamanak՝ 2018t., ev tshanachvel e anvtang, teev qich ardyunavetutyamb, qan monoklonayin hakamarminnere:

Nor hetazotutyune manramasn nkaragrum e dexamijotsi ashxatanqi mexanizmnere: Gitnakanneri xosqov՝ remdisivire xabum e virusnerin՝ nmanakelov karutsoxakan spitakutsneri: Ashxatanqi hexinaknerits Matias Geten koronavirusi fermentnere nkaragrelis nshel e, or koronavirusayin polimeraznere shat anpuyt en ev nrants moloretsnele hesht e: Oւsti zspume (inhibitor) mianum e (replikatsiayi pulum) shat angam, ev virusn aylevs i vitshaki che bazmanalu:

Hetazotutyunn irakanatsvel e SARS-CoV-2-i maqrvats RNT-polimerazi vra: Fermentn aktivoren miatsrel e remdesivire (aveli hstak՝ nra erafosfatayin karutsvatsqe)՝ ayn texadrelov RNT-um՝ nukleotidnerits meki poxaren: Da ir hertin hangetsrel e nran, or 3 nukleoti heto nerdrvats remdesiviri pattsharov RNT-polimerazn arden chi karoxatsel araj sharzhvel sintezavorvox shxtayov, ev RNT-i sintezn argelapakvel e:

Remdesiviri arantsqayin arandznahatkutyunn bardzr entroxakanutyunn e (kensaqimiakan entroxakanutyun): Aystex ayn aveli ardyunavet e, qan aydpisi hakavirusayin dexamijotsi erafosfatayin karutsvatsqnere, inchpes sofosbuvire, favipiravire ev ribavirine:

Hetazotutyan hexinakneri kartsiqov՝ nrants ardyunqnere, oronq amraktsvel en aveli vax modelayin kendanineri ev bjjayin mshakumneri vra arvats ashxatanqneri tvyalnerin, vkayum ayn masin, or remdesivire kareli e dasakargel orpes «anmijakan gortsoxutyan hakavirusayin mijots»: Ayd paste gitnakannerin vstahutyun e haxordum klinikakan pordzarkumneri hamar, oronq nerkayums irakanatsvum en ashxarhi miazhamanak mi qani erkrnerum, ayd tvum՝ Rusastanum:

Gitnakane naxazgushatsnum e, or laboratoriayum statsvats drakan ardyunqnere chen karox tsarayel mardkants depqum kanxatesman hamar: Nra xosqov՝ petq e hamberutyamb ltsvel ev spasel mardkants vra patahakan entrutyamb arvats klinikakan hetazotutyunneri avartin: