Kensabannere nematodneri kyanqe erkaratsrel en 500 tokosov
C. elegans nematodneri (klor order) kyanqi tevoxutyune sovorabar chi gerazantsum 2-3 shabate, sakayn gitnakannerin hajoxvel e ayn erkaratsnel mi qani angam:
Verjers hajoxvel e krknapatkel Caenorhabditis elegans-i kyanqi tevoxutyune՝ arhestakanoren tshnshelov DAF-2 geni eqspresian: Endunichnere, oronq kodavorum en ays gene, arantsqayin der en xaxum insulini (IIS) azdanshanayin uxu ashxatanqum: Orderi kyanqi tevoxutyan erkaratsman, teev och aydqan nshanakalits, hangetsnum e naev ayl azdanshanayin spitakutsi՝ RSKS-1 geni aktivutyan tshnshume: Ayn masnaktsutyun uni rapamitsini (TOR) azdanshananayin uxum:
Nor hetazotutyan hexinaknere inhibatsrel en (inhibere — kangnetsnum em, zspum em) erku genere miazhamanak: MDI-i kensaban Jarod Rolinse nshel e, or sinergetik ardyunqn anhavatali e exel:
Gitnakani xosqov՝ sa hertakan angam tsuyts e talis, or tseratsume hetevanq e och miayn hstak geni kam spitakutsi, ev och mek hstak azdanshanayin uxu, bayts tsagum e drants bard poxazdetsutyunits:
Hexinaknere tsuyts en tvel, or DAF-2-i ev RSKS-1-i tshnshume hangetsnum e GLD-1 azdanshanayin spitakutsi aktivatsmane: Ayn ir hertin nvazetsnum e c tsitroqromi aktivutyune ev tanum mitoqondriumneri stresayin pashtpanutyan mexanizmneri meknarkin, inchn ardyunavet kerpov «maqrum» e hin spitakutsnerits: Batsi ayd, aktivanum en proteinkinaznere: Verjinners npastum en bjijneri antsmann aravel xnayox kargavitshaki:
IIS ev TOR azdanshanayin uxinere bardzr konservativutyun unen ev qich en tarbervum nuynisk tarber organizmneri mot, orinak՝ mardkants ev C.elegans-i: Ayd pattsharov el kartshakyatsnere hamematabar sovorakan order en ev tseratsman hetazotutyan hamar npastavor model en: Chnayats dran, derevs chi kareli hstak asel՝ IIS-i ev TOR-i nkatmamb mijamtutyune tuyl kta՞ ardyoq erkaratsnel mardkants kyanqn aydpes eakanoren՝ minchev 400-500 tari:
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