Chinatsi hetazotoxnere batsatrel en SARS-CoV-2-i batsasakan azdetsutyan mexanizme ev nra het kapvats 2 dexamijotsneri ardyunavetutyune

Sichuani hamalsaranits Venchzhun Lyui ev Ibinyan hamalsaranits Hualan Lii koxmits katarvats hetazotutyune tsuyts e talis, or SARS-CoV-2 viruse karox e hardzakum gortsel mardu eritrotsitneri vra՝ kapvelov hemoglobini molekulneri het: Da hangetsnum e aryunatarov ttvatsni texapoxman xaxtmane:

Gemoglobine metax parunakox bard spitakuts e, orn unak e hetadardzutyamb kapvel ttvatsni het: Hemoglobini yuraqanchyur molekuli kentronum hemn e (aryun) kam porfirinayin mijuke, ore parunakum e erkvalent erkati atom. ayn unak e amrakapelu 4 hat O₂ molekulneri: Toqerum havaqelov ttvatsin՝ eritrotsitnere hemoglobini ognutyamb ayn texapoxum en marmni tarber maser u organner:

SARS-CoV-2-i virusayin masniknern eritrotsitneri het anmijapes chen poxazdvum: Dra hamar patasxanatu en mi sharq och karutsvatsqayin (virusayin kapsidi mas chhandisatsox) spitakutsner, oronq kodavorum en virusayin RNT-n: Nman proteinnere heshtatsnum en tiroj organizmum virusi amratsman ev krknapatkman gortse՝ argelapakelov bjjayin mexanizmnere ev kensaqimiakan uxinere:

Chinatsi gitnakannere parzel en, or ayd och karutsvatsqayin virusayin spitakutsnerits oroshnere mutq en gortsum eritrotsitneri mej ev porfirinayin mijuknerits erkate durs en berum: Da aryunayin karmir masniknerin zrkum e ttvatsi matakararman hnaravorutyunits: Hetazotoxnerin hajoxvel e nuynakanatsnel 3 aydpisi proteinneri՝ orf1ab, ORF10 ev ORF3a, oronts kape hemoglobini molekuli beta shxtayi het hangetsnum e erkati tarrabazhanmane: Hemi het kapvelun karox en masnaktsel virusi makeresayin glikoproteine ev ORF8 spitakutse:

Nman poxazdetsutyune hangetsnum e toqerum borboqayin gortsentatsneri uzhgnatsmane, terttvatsnaryunutyane (hipoqsemia), sur shncharakan distres-hamaxtanishi (SShDH) axtanshanneri zargatsmane ev bazmaorganayin ttvatsnayin anbavararutyane: Virusayin spitakutsneri amraktsume hemi het batsatrum e naev koronavirusov arants axtanshanneri hivandatsatsneri mot ayspes kochvats antapants apaku axtanshani i hayt gale. ayn artahaytvum e toqayin hyusvatsqi tapantsikutyan nvazmamb՝ paymanavorvats toqabshtikneri odaynutyan nvazmamb ev toqabshtiknerum hemoglobini kutakmamb: Porfirinayin mijuki vra virusi azdetsutyan anuxxaki nshan e naev orosh hivandneri aryan mej erkat parunakox feritin spitakutsneri shatatsume:

Nor batsahaytume batsatrum e hidroqsiqloroqini ev favipiraviri ardyunavetutyune Covid-19-i buzhman hamar: Verjers fransiatsi gitnakan Didye Raule haytararel er, or malarian buzhox hidroqsiqloroqini mijotsov aveli qan 1000 mard buzhvel e koronavirusits: Lyui ev Lii hastatman hamadzayn` qloroqinn unak e argelapakelu orf1ab, ORF3a ev ORF10 spitakutsneri hardzakume, inchpes naev kanxargelel hemoglobini het ORF8-i miatsume: Da tuyl e talis nvazetsnel virusayin varaki batsasakan azdetsutyune toqeri vra ev organizmi vra՝ endhanrapes:

Inch veraberum e favipiravirin, apa ayn hakavirusayin dexamijots e՝ hajoxvats bazmativ RNT virusneri dem payqarum: Ayn aravel uxxordvats gortsoxutyun e tsutsaberum SARS-CoV-2-i dem, argelapakum e makeresayin glikoproteinnere ev ORF7a virusayin spitakutsnere՝ virusin tuyl chtalov nertapantsel bjji mej, isk nra spitakutsin՝ dzevapoxel hemoglobini molekulnere:

Lii ev Lyui koxmits nerkayatsvats՝ virusayin spitakutsnere miatsnox mexanizme karox e himq handisanal ayn fenomeni, or erexanere hatshax tetev en tanum koronavirusayin varake: Inchpes vere nshvel e, virusayin spitakutsnere erkate tarralutsum en՝ poxazdvelov hemoglobini beta shxtayi het: Verjins handisanum e HbA-yi՝ hasun mardu normal hemoglobini karutsvatsqayin mase: Erexaneri aryan mej gerakshrum e ayspes kochvats fetalayin HbF hemoglobine, ore beta shxtaner chuni ev, havanabar, xotseli che virusayin spitakutsneri hamar:

Hnaravor e՝ hemoglobini karutsvatsqi nman arandznahatkutyune paymanavorum e Afrikayi orosh erkrnerum varakvatsutyan och bardzr makardake: Ayn shrjannerum, ortex malarian taratsvats e, shat en talasemiayov hivandnere: Ayn genetik hivandutyun e, ori kroxi mot sintezvum e mutantayin hemoglobin՝ arants beta shxtaneri:

Hetazotoxneri ezrakatsutyunnere karox en hangetsnel Covid-19-ov tsanr hivandneri buzhman martavarutyan veranaymane: Havanabar՝ toqeri odapoxman endunvats metode ev SShDH-i depqum shncharakan ajaktsutyune karox en vnasel koronavirusayin toqaborbov hivandin՝ vnaselov toqere: Ete nerkayatsvats ezrakatsutyunnere tshisht en, apa aveli ogtakar karox en linel aryan poxnerarkume ev patsientneri hiperbarik oqsigenatsian:

Chinatsi gitnakanneri ashxatanqe spasum e graxosutyane, ev ezrakatsutyunneri tshshmartatsiutyune petq e hastatvi ayl hetazotutyunnerov: Ashxatutyan hexinaknere naev pndum en, or petq che inqnuruyn sksel favipiravirov ev hidroqsiqloroqinov buzhume. xorhurd en talis dranq ogtagortsel miayn bzhshki tsutsumov: